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3/28/24

Inflammation - Medical Animation

 

This animation may only be used in support of a single legal proceeding and for no other purpose. Read our License Agreement for details. To license this image for other purposes, click here.

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Item #ANM11028 — Source #1083

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Inflammation - Medical Animation
MEDICAL ANIMATION TRANSCRIPT: Inflammation is a local immune response to tissue injury or infection, experienced as heat, redness, edema, pain, and loss of function. Immediately after injury, inflammation begins with brief vasoconstriction of the local blood vessels to reduce blood loss and formation of a clot to stop the bleeding. Then, stimulated by cell injury and death, local cells release vasoactive chemicals, such as prostaglandins and histamine to dilate local blood vessels leading to increased blood flow to the area. These chemicals also cause endothelial cells in small blood vessels to contract, opening spaces between them. This increased capillary permeability allows fluids and proteins to pass from the blood into the tissue. Next, during a multi-stage process called chemotaxis, circulating immune cells called neutrophils move out of the blood vessels to the site of injury and destroy pathogens and damaged cells. Chemotaxis begins when cells at the injury site release messenger molecules called chemoattractants, which cause local endothelial cells and circulating neutrophils to stick together. Next, in a process called diapedesis, neutrophils squeeze through the endothelial gaps. The neutrophils migrate to the injury site by following a chemotactic gradient. Upon arrival, the neutrophils encounter bacteria, engulf them and digest them in a process called phagocytosis. After destruction of the bacteria and removal of cellular waste, tissue repair begins when locally produced growth factors cause local fibroblasts to begin dividing rapidly and secreting large quantities of collagen to reinforce the wound. Anti-inflammatory drugs inhibit inflammation by blocking production of inflammatory chemicals. The most common drugs for inflammation are non-steroidal anti-inflammatory drugs, or NSAIDS, such as aspirin and ibuprofen. They contain an enzyme called cyclooxygenase or COX, that inhibits the production of prostaglandins and several other inflammatory chemicals. Thus, reducing vasodilation, edema, and pain associated with inflammation.

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What attorneys say about MLA and The Doe Report:
"I wanted to thank you for the terrific job you did illustrating my client's injuries. The case was settled at the pre-suit mediation, and I believe a good part of the success we had was due to the medical legal art you prepared.

Your work received the ultimate compliment at the conclusion of the mediation. The hospital risk manager took the exhibit with them at the conclusion of mediation, and will be using it to train nurses on how to prevent bed sores..."

Steven G. Koeppel
Troy, Yeslow & Koeppel, P.A.
Fort Myers, FL

"A few words about The Doe Report: recently in a brachial plexus injury case, we used an image from The Doe Report to demonstrate the injury. We downloaded the PDF file image, and were amazed at the quality. The hard copies that you sent were even more clear. As well, we could not have been happier when you customized the image and reversed the injury from the left shoulder to the right shoulder, which is where our client's injury was.

The speed and cost-effectiveness of the product made it the perfect tool for our purposes. We will use The Doe Report again in future cases."

Andrew Needle
Needle Gallagher & Ellenberg, P.A.
Miami, FL

"It is with great enthusiasm that I recommend Medical Legal Art. We have used their services for three years and always found their professionalism, quality of work, and timely attention to detail to exceed our expectations. We recently settled two complicated catastrophic injury cases. One medical malpractice case involving a spinal abscess settled for 3.75 million and the other involving injuries related to a motor vehicle accident settled for 6.9 million. We consider the artwork provided by MLA to have been invaluable in helping us to successfully conclude these cases.

I highly recommend MLA to anyone seeking high quality, detailed medical legal artwork."

E. Marcus Davis, Esq.
Davis Zipperman, Krischenbaum & Lotito
Atlanta, GA
www.emarcusdavis.com

"Thank you very much for the great work on the medical exhibits. Our trial resulted in a $16 million verdict for a 9 year old boy with catastrophic injuries, and the medical illustrations definitely played key role in the trial."

David Cutt
Brayton Purcell
Salt Lake City, UT

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