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MEDICAL ANIMATION TRANSCRIPT: Inflammation is a local immune response to tissue injury or infection, experienced as heat, redness, edema, pain, and loss of function. Immediately after injury, inflammation begins with brief vasoconstriction of the local blood vessels to reduce blood loss and formation of a clot to stop the bleeding. Then, stimulated by cell injury and death, local cells release vasoactive chemicals, such as prostaglandins and histamine to dilate local blood vessels leading to increased blood flow to the area. These chemicals also cause endothelial cells in small blood vessels to contract, opening spaces between them. This increased capillary permeability allows fluids and proteins to pass from the blood into the tissue. Next, during a multi-stage process called chemotaxis, circulating immune cells called neutrophils move out of the blood vessels to the site of injury and destroy pathogens and damaged cells. Chemotaxis begins when cells at the injury site release messenger molecules called chemoattractants, which cause local endothelial cells and circulating neutrophils to stick together. Next, in a process called diapedesis, neutrophils squeeze through the endothelial gaps. The neutrophils migrate to the injury site by following a chemotactic gradient. Upon arrival, the neutrophils encounter bacteria, engulf them and digest them in a process called phagocytosis. After destruction of the bacteria and removal of cellular waste, tissue repair begins when locally produced growth factors cause local fibroblasts to begin dividing rapidly and secreting large quantities of collagen to reinforce the wound. Anti-inflammatory drugs inhibit inflammation by blocking production of inflammatory chemicals. The most common drugs for inflammation are non-steroidal anti-inflammatory drugs, or NSAIDS, such as aspirin and ibuprofen. They contain an enzyme called cyclooxygenase or COX, that inhibits the production of prostaglandins and several other inflammatory chemicals. Thus, reducing vasodilation, edema, and pain associated with inflammation.
"I wanted to thank you for the terrific job you did illustrating my client's
injuries. The case was settled at the pre-suit mediation, and I believe a
good part of the success we had was due to the medical legal art you
prepared.
Your work received the ultimate compliment at the conclusion of the mediation. The hospital risk manager took the exhibit with them at the
conclusion of mediation, and will be using it to train nurses on how to
prevent bed sores..."
Steven G. Koeppel Troy, Yeslow & Koeppel, P.A. Fort Myers, FL
"A few words about The Doe Report: recently in a brachial plexus injury
case, we used an image from The Doe Report to demonstrate the injury. We
downloaded the PDF file image, and were amazed at the quality. The hard
copies that you sent were even more clear. As well, we could not have been
happier when you customized the image and reversed the injury from the left
shoulder to the right shoulder, which is where our client's injury was.
The speed and cost-effectiveness of the product made it the perfect tool for
our purposes. We will use The Doe Report again in future cases."
Andrew Needle
Needle Gallagher & Ellenberg, P.A.
Miami, FL
"It is with great enthusiasm that I recommend Medical Legal Art. We have
used their services for three years and always found their professionalism,
quality of work, and timely attention to detail to exceed our expectations.
We recently settled two complicated catastrophic injury cases. One medical
malpractice case involving a spinal abscess settled for 3.75 million and the
other involving injuries related to a motor vehicle accident settled for 6.9
million. We consider the artwork provided by MLA to have been invaluable in
helping us to successfully conclude these cases.
I highly recommend MLA to anyone seeking high quality, detailed medical
legal artwork."
E. Marcus Davis, Esq.
Davis Zipperman, Krischenbaum & Lotito
Atlanta, GA www.emarcusdavis.com
"Thank you very much for the great work on the medical exhibits. Our trial
resulted in a $16 million verdict for a 9 year old boy with catastrophic
injuries, and the medical illustrations definitely played key role in the
trial."
Medical Legal Art creates medical demonstrative evidence (medical
illustrations, drawings, pictures, graphics, charts, medical animations,
anatomical models, and interactive presentations) for use during legal
proceedings, including research, demand letters, client conferences,
depositions, arbitrations, mediations, settlement conferences, mock jury
trials and for use in the courtroom. We do not provide legal or medical
advice. If you have legal questions, you should find a lawyer with whom you
can discuss your case issues. If you have medical questions, you should seek the advice of a healthcare provider.