Back to home page



or
Search Language
Browse
Medical Illustrations
Medical Exhibits
Medical Animations
Medical Animation Titles
Medical Encyclopedia
Most Recent Uploads
Body Systems/Regions
Anatomy & Physiology
Cells & Tissues
Abdomen
Back and Spine
Foot and Ankle
Hand and Wrist
Head and Neck
Hip
Knee
Shoulder
Thorax
Medical Specialties
Anesthesiology
Cancer
Cardiology
Dentistry
Emergency Medicine
Gastroenterology
Infectious Diseases
Neurology/Neurosurgery
Nursing Home
Ob/Gyn
Orthopedics
Pathology
Pediatrics
Personal Injury
Plastic Surgery
Psychiatry
Radiology
Surgery
Urology/Nephrology
Account
Administrator Login
 
3/29/24

Medication Distribution - Medical Animation

 

This animation may only be used in support of a single legal proceeding and for no other purpose. Read our License Agreement for details. To license this image for other purposes, click here.

Ready to License?

Item #ANM10008 — Source #1083

Order by phone: (800) 338-5954

Medication Distribution - Medical Animation
MEDICAL ANIMATION TRANSCRIPT: Distribution is the process by which a medication is carried to its target tissue or site of action with the goal of causing a therapeutic response. This process follows medication absorption and precedes medication metabolism. Medication is first carried to highly vascularized tissues including the liver, heart, kidneys, and brain. Then medication is widely circulated within the body, reaching areas of less extensive blood supply such as skin, muscle, and fat. Medication then accumulates in the fat and in poorly vascularized tissues like bone, especially if the medication is lipophilic or strongly attracted to lipids. In the blood, some medication molecules bind to plasma proteins to which they are attracted. In this bound state, medication molecules are unable to produce a pharmacological effect. In bound and unbound form, the medication flows through the arteries and into capillaries. Capillaries carry the medication close to the tissue's cells, where hydrostatic pressure drives molecules between the capillary endothelial cells into the interstitial space. Some protein-bound macromolecules are too large to pass through the vessel walls, so they never reach the target tissue. Unbound or free molecules do reach the target tissue by exiting the bloodstream between the loss junctions in the capillary endothelium into the interstitial space to interact with the tissue cells. Some molecules bind to the cells while others remain in the extracellular fluid. The interaction of the unbound medication with the target tissue results in a therapeutic response. There are many factors that affect distribution. For example, the effect of membrane permeability on distribution can be demonstrated in the brain. The brain's capillaries are impermeable to the majority of medications due to the blood-brain barrier, a membrane that blocks the entrance of both toxic and therapeutic substances into brain tissues. Some medications penetrate the blood-brain barrier based on features like low polarity and high solubility in lipids. Fat-soluble molecules cross cell membranes faster than water-soluble molecules due to the lipophilic nature and phospholipid composition of the cellular membrane. Factors such as body fat percentage and disease also affect medication distribution. Fat deposits retain lipid-soluble unionized medication and release the molecules over time. Thus, obese patients may experience prolonged pharmacologic effects. Inflammation, disease, and injuries such as burns can alter protein levels and thus medication binding, increasing capillary permeability and uptake in cells and tissues. As a complication of kidney disease, albumin cannot bind medications effectively, resulting in a low percentage of protein-bound medication. These shifts result in high levels of free medications circulating throughout the body.

YOU MAY ALSO WANT TO REVIEW THESE ITEMS:
Nerve Distribution of the Bladder and Uterus
Nerve Distribution of the Bladder and Uterus - exh4521a
Medical Exhibit
Add to my lightbox
Find More Like This
Placement of Multiple Tubes for Intravenous Medication and Abscess Drainage
Placement of Multiple Tubes for Intravenous Medication and Abscess Drainage - exh5214b
Medical Exhibit
Add to my lightbox
Find More Like This
Distribution of the Trigeminal Nerve
Distribution of the Trigeminal Nerve - CC00044
Medical Illustration
Add to my lightbox
Find More Like This
Severe Hypothesia of the Left V2/V3 Distribution
Severe Hypothesia of the Left V2/V3 Distribution - exh63041a
Medical Exhibit
Add to my lightbox
Find More Like This
Discontinuation of Anticoagulant Medication with Subsequent Thrombus
Discontinuation of Anticoagulant Medication with Subsequent Thrombus - exh61553d
Medical Exhibit
Add to my lightbox
Find More Like This
Heart Failure Treatment: Medication
Heart Failure Treatment: Medication - ANH14129d
Medical Animation
Add to my lightbox
Find More Like This
What attorneys say about MLA and The Doe Report:
"Your firm is great to work with and, most importantly for me, you get the job done on time and with the utmost professionalism. You should be proud of all those you employ, from KJ to Ben B. I've been especially pleased over the years with the work of Brian and Alice, both of whom seem to tolerate my idiosycratic compulsion to edit, but I've not found a bad apple in the bunch (and, as you know, I've used your firm a bunch!). I look forward to our continued professional relationship."

Kenneth J. Allen
Kenneth Allen & Associates
Valparaiso, IN

"Thank you very much for the great work on the medical exhibits. Our trial resulted in a $16 million verdict for a 9 year old boy with catastrophic injuries, and the medical illustrations definitely played key role in the trial."

David Cutt
Brayton Purcell
Salt Lake City, UT

"I have found that the personalized medical illustrations prepared by Medical Legal Art have been very accurate and helpful. The medical doctors, both treating physicians and expert witnesses, have commented on the accuracy and professionalism of the medical illustrations. Most importantly, your prompt service and attention upon even short notice has been tremendous. I can certainly say that the medical illustrations prepared by Medical Legal Art have assisted us in bringing cases to a successful resolution."

Paul L. Redfearn
The Redfearn Law Firm, P.C.
Kansas City, MO

"Medical Legal Art wins our firm's highest accolades for professionalism and exhibit quality. In fact, many of the doctors I work with request color copies of your outstanding artwork to show to patients during the informed consent process."

Jeanne Dolan, BSRN, AlNC
Legal Nurse Consultant
Golden Valley, MN

Medical Legal Blog |Find a Lawyer | Hospital Marketing